Shiro Sanada is the science officer serving aboard the space battleship Yamato. The name may refer to:
- Shiro Sanada (OS), an Earth Defense Force officer, serving as head of Yamato's scientific division, and EDF commander
- Shiro Sanada (2199), a United Nations Cosmo Force officer, serving as head of Yamato's scientific division and commanding officer of Hyuga
- Shiro Sanada (live action film), an Earth Defense Force officer, serving as head of Yamato's scientific division