The First Battle of Pluto was a battle fought against attacking aliens in the vicinity of Pluto in early 2199 that resulted in a catastrophic loss of ships from Earth. The name may refer to:
- The First Battle of Pluto (OS), launched by the Earth Defense Force (OS) against military vessels of the Gamilas Empire as a desperate last offensive, in the original Space Battleship Yamato
- The First Battle of Pluto (2199), launched by the United Nations Cosmo Navy against the Great Imperial Garmillas Astro Fleet as a decoy operation, in Space Battleship Yamato 2199