Dessler is the absolute ruler of an interstellar empire threatening Earth in the year 2199 and beyond. The name may refer to:
- Dessler (OS), leader of the Gamilas Empire and its remnants and an adversary-turned-ally of the Yamato crew in the original Space Battleship Yamato and its sequels
- Abelt Desler, leader of the Greater Garmillan Empire until his exile from Garmillas in Space Battleship Yamato 2199 and Space Battleship Yamato 2202: Warriors of Love
- Dessla, personification of half of the Gamilas hive mind in Space Battleship Yamato (live action film)